Effect of Vitamin D for Symptomatic Osteoarthritis Study
January 9, 2013
ABSTRACT
Importance Knee osteoarthritis (OA), a disorder of cartilage and periarticular bone, is a public health problem without effective medical treatments. Some studies have suggested that vitamin D may protect against structural progression.
Objective To determine whether vitamin D supplementation reduces symptom and structural progression of knee OA...
Results Eighty-five percent of the participants completed the study...
...Conclusion and Relevance Vitamin D supplementation for 2 years at a dose sufficient to elevate 25-hydroxyvitamin D plasma levels to higher than 36 ng/mL, when compared with placebo, did not reduce knee pain or cartilage volume loss in patients with symptomatic knee OA.
